|
|
4-[4-(N-BOC)哌嗪-1-基]苯基硼酸頻哪酯 |
| CAS No.: |
470478-90-1 |
| 分子式： |
C21H33BN2O4 |
| 分子量： |
388.32 |
| 備注： |
中文名稱4-[4-(N-BOC)哌嗪-1-基]苯基硼酸頻哪酯中文同義詞4-(4-BOC-1-哌嗪基)苯硼酸頻哪醇酯;4-[4-(N-BOC)哌嗪-1-基]苯基硼酸頻哪酯;4-(4-叔丁氧羰基哌嗪)苯硼酸頻那醇酯;4-[4-(N-叔丁氧羰基)哌嗪-1-基]苯硼酸頻哪醇酯;4-(4-叔丁氧羰基哌嗪基)苯硼酸嚬哪醇酯;4-(4-(N-BOC)哌嗪-1-基)苯基硼酸頻哪醇酯;4-(4-(4-(4,4,5,5-四甲基-1,3,2-二氧雜硼烷-2-基)苯基)哌嗪-1-羧酸叔丁酯;4-((4-BOC)哌嗪基)苯硼酸頻哪酯英文名稱4-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONICACID,PINACOLESTER英文同義詞TERT-BUTYL4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE;4-(4-BOC-PIPERAZINYL)PHENYLBORONICACIDPINACOLESTER;4-Piperazin-1-ylbenzeneboronicacidpinacolester,N4-BOCprotected90%;4(N-TERT-BUTOXYCARBONYLPIPERAZINE)BENZENEBORONICACIDPINACOLESTER;4-Piperazin-1-ylbenzeneboronicacidpinacolester,N4-BOCprotected;Tert-butyl4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)tetrahydro-1(2H)-pyrazineChemicalbookcarboxylate;4-[4-(N-Boc)piperazin-1-yl]phenylboronicacidpinacolester;t-butyl4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazinecarboxylateCAS號470478-90-1分子式C21H33BN2O4分子量388.31EINECS號相關類別Aryl;Boronicester;OrganoboronsMol文件470478-90-1.mol結構式4-[4-(N-BOC)哌嗪-1-基]苯基硼酸頻哪酯性質熔點157°C沸點501.7±45.0°C(Predicted)密度1.11儲存條件Keepindarkplace,Sealedindry,RoomTemperature酸度系數(pKa)3.06±0.10(Predicted)形態(tài)固體顏色灰白色至淺黃色InChIKeyZMAVVXGWEHZLDW-UHFFFAOYSA-N4-[4-(N-BOC)哌嗪-1-基]苯基硼酸頻哪酯用途與合成方法用途4-(4-Boc-1-哌嗪基)苯硼酸頻哪醇酯是Suzuki交叉偶聯反應的重要原料，可以與含有a，β不飽和鍵的羧基化合物進行共軛加成反應，廣泛用于醫(yī)藥化工領域。制備以5-溴-2-(4-Boc-哌嗪-1-基)嘧啶為原料、聯硼酸頻哪醇酯［B2(pin)2］為硼試劑、K3PO4·7H2O為堿，在氯(2-二環(huán)己基膦基-2’，4’，6’-三異丙基-1，1’-聯苯基)［2-(2’-氨基-1，1’-聯苯)］鈀(Ⅱ)(Xphos-Pd-G2)和2-二環(huán)己基磷-2’，4’，6’-三異丙基聯苯(Xphos)體系的催化下合成了4-[4-(N-BOC)哌嗪-1-基]苯基硼酸頻哪酯。其合成反應式如下圖： |
| 結構式： |
 |
 |
|
聲明：以上信息未經本網證實,僅供參考,華夏化工網不承擔任何風險責任. |
|
